Suspected bacterial problems such as fin rot, tail rot, ulcers and pop-eye
Form
Tablets, 500 mg each
Count sizes
30 count, 60 count
Water type
Freshwater and saltwater
Made in
United States by Aqua Soma Labs
Fix Pen is an antibacterial treatment for ornamental aquarium fish and non-food pet birds. Each tablet contains 500 mg of Penicillin V Potassium, made by Aqua Soma Labs in the United States and sold in bottles of 30 or 60 tablets with fresh expiration dates.
Aquarists may know this product as Fish Pen, Fish Pen Forte, Aqua Pen or FISHBIOTIC Penicillin. Those were Thomas Labs brand names, and Fix Pen is the current replacement now that the Thomas Labs line is discontinued. Keepers usually reach for penicillin tablets for fish when they see fin rot, tail rot, infected wounds, pop-eye (bulging eyes) or columnaris-type lesions, sometimes called cotton-wool disease, where a bacterial cause is suspected.
Penicillin V works on the cell walls of certain bacteria and can stop certain gram-positive bacteria from multiplying. Fix Pen is the fish penicillin 500 mg tablet many hobbyists use for fish tank infections, and the same tablets are used as penicillin for birds under avian veterinary guidance. It targets gram-positive and some gram-negative bacteria in ornamental aquarium use.
Each tablet contains 500 mg, and bottles come in 30 or 60 tablets. The 30-count suits a single hospital tank or occasional use; the 60-count fits multi-tank setups or aviary needs. You can buy Fix Pen online with fresh expiration dates and U.S. shipping.
Start treatment early, at the first signs of a suspected bacterial problem. The signs are not the same for fish and birds, so use the lists below to know what to watch for.
Soft tissue infections where a vet suspects bacteria
Fluffed-up feathers, lethargy or inactivity
Decreased appetite
For birds, only reach for Fix Pen when an avian veterinarian has recommended penicillin for a specific problem. Catching an infection early, paired with clean water and good husbandry, gives your fish and birds the best chance to recover.
Husbandry still does most of the work. Stable water and good feeding prevent more problems than any treatment can fix. Penicillin does nothing for viral issues, and using fish treatments like penicillin when they are not needed can reduce how well they work later.
Order online: in-stock orders placed before 1:30 p.m. CT, Monday through Friday, ship the same day from our U.S. warehouse by USPS or UPS.
Important Notice: This product is intended for aquarium and ornamental fish and pet birds only. It is not for animals used for food.
Fish Pen Forte vs Fix Pen: What Changed?
If you used Thomas Labs Fish Pen, Fish Pen Forte, Aqua Pen or FISHBIOTIC Penicillin, here is what is the same and what is different:
Same Penicillin Formula Fix Pen contains the same 500 mg Penicillin V Potassium per tablet that you used in Fish Pen and Fish Pen Forte. The formula targets the same bacteria.
New Manufacturer Fix Pen is made by Aqua Soma Labs, which replaced the discontinued Thomas Labs line. Aqua Soma Labs manufactures it in the United States.
Same Tablet Form Fix Pen uses the same tablet format as the original Fish Pen, so it is easy to dissolve in aquarium water or crush for precise dosing in a hospital tank.
Available in 30-Count and 60-Count Bottles Pick the size that fits your setup: a 30-count bottle for a single hospital tank or occasional use, or a 60-count bottle for larger collections, multi-tank operations or aviary needs.
Benefits of Fix Pen for Fish & Birds
Targeted Gram-Positive Bacterial Coverage
A classic penicillin choice when a gram-positive bacterial component is suspected in ornamental fish, especially when the signs look like fin and tail rot, mouth rot, sores, pop-eye or cloudy eyes.
Made in the USA with Fresh Dating
Fix Pen is manufactured in the United States by Aqua Soma Labs and ships with fresh expiration dates, so you can keep a bottle on hand for your hospital tank and trust it when you need it.
Consistent 500 mg Tablets
Each tablet delivers a reliable 500 mg dose of Penicillin V Potassium, so it is easy to scale from a single betta or quarantine tank to larger community aquariums.
Common Aquarium Use Cases
Often chosen when the goal is to target gram-positive and some gram-negative bacteria in ornamental fish. In aquarium care discussions, penicillin comes up for flexibacter-type issues, infected wounds and worsening fin damage when a bacterial component is suspected.
Freshwater and Saltwater Compatible
Made for ornamental aquarium use in both freshwater and saltwater setups when used as directed. A separate hospital tank is still recommended when possible to protect the main display system.
Quarantine-Friendly and Biofilter Aware
Penicillin may affect beneficial bacteria and can be risky for invertebrates like shrimp and snails. A separate treatment tank protects the main display and makes water-quality monitoring easier during treatment.
Ideal for Hospital Tanks and Quarantine
Treating in a separate hospital tank keeps the main aquarium's biofilter intact and limits exposure for healthy tank mates, so you can focus the treatment where it is needed.
Usage Guidelines & Instructions
Quick usage summary for fish: Use 1 tablet per 20 gallons (76 L), repeat every 24 hours, and do a partial water change between doses. Continue for 5 to 10 days, and stop if you see no improvement after 5 days.
Directions for Use:
Set Up a Separate Treatment Area
When possible, treat fish in a hospital or quarantine tank. This limits exposure for healthy tank mates and makes it easier to watch results and water quality. Remove activated carbon and turn off UV sterilizers during treatment, since they can strip the penicillin from the water.
Directions for Fish Aquariums
Dissolve one (1) 500 mg tablet in a small cup of aquarium water first, then add the dissolved dose for every 20 gallons (76 L) of water you are treating. Repeat every 24 hours, with a partial water change between treatments.
Duration and When to Stop
Continue for 5 to 10 days. If you see no improvement after 5 days, stop and consider asking an aquatic professional about next steps. Finish the full recommended number of days even if the fish look better, since stopping early can let the problem come back.
Maintain Water Quality During Treatment
Keep strong aeration and watch your water parameters, especially ammonia and nitrite. Because penicillin may affect beneficial bacteria and can be risky for invertebrates like shrimp and snails, a separate treatment tank and close observation are strongly recommended.
Pet Birds (Under Veterinary Guidance Only)
For non-food pet birds, use penicillin only under avian veterinary guidance for amount, frequency and duration. Your vet can advise the correct amount for the bird's weight and decide whether to treat a single bird or the whole flock.
Fix Pen Amounts by Aquarium Size
Tank volume
Penicillin per use
500 mg tablets
10 gallons (38 L)
250 mg
half a tablet (split)
20 gallons (76 L)
500 mg
1
40 gallons (151 L)
1000 mg
2
60 gallons (227 L)
1500 mg
3
75 gallons (284 L)
about 1875 mg
about 4
These amounts follow the label guideline of one 500 mg tablet per 20 gallons (76 L), roughly 25 mg per gallon. Dose by the water volume of your treatment tank, not by the number of fish, give one dose every 24 hours for 5 to 10 days, and make a partial water change between doses. Splitting a tablet by hand is only approximate, so for tanks under 20 gallons it is better to dissolve a whole tablet in a measured cup of tank water and add the matching fraction. Continuing for the full recommended number of days matters as much as picking the right treatment. The bottle label or your aquatic veterinarian takes priority over this quick-reference chart.
What to Expect During Treatment
Days 1 to 2
Fish may hide or eat less, and the water can look slightly cloudy. This is normal early on. Keep dosing on schedule and keep aeration strong.
Days 3 to 5
Look for signs it is working: sores and red patches stop spreading, appetite starts to return, and breathing steadies. If there is no change by day 5, or the fish look worse, stop and ask an aquatic professional.
Days 5 to 10
Even if the fish are improving, finish the full treatment so the infection does not return. Afterward, run a partial water change and put activated carbon back in to clear any leftover penicillin.
Fix Pen treatment timeline: a typical 5 to 10 day treatment for aquarium fish, with a reassessment point at day 5.
What You Need for Treatment
A little setup before the first dose saves trouble later.
A separate hospital or quarantine tank, so you are not treating the whole display.
A heater and an air stone or sponge filter for steady temperature and strong aeration.
An ammonia and nitrite test kit to keep tabs on water quality.
A dechlorinator for the water changes between doses.
A small net and a clean cup for gentle transfer and measuring the dose.
Pro Tip: Dose by the actual treated water volume, not the tank's advertised size, since gravel, decorations and equipment reduce usable volume. Daily observation and stable water quality matter as much as the dose.
How Fix Pen Works
Each Fix Pen tablet contains 500 mg of Penicillin V Potassium, a penicillin that acts on the cell walls of certain bacteria. It helps control certain gram-positive bacteria, and some gram-negative bacteria, when used as directed in ornamental fish care.
The rest of each tablet is made up of standard ingredients that hold it together on the shelf and let it break apart and dissolve when you add it to aquarium water or a treatment setup.
Safety and Tank Notes
When used as directed, Fix Pen usually causes no problems in ornamental fish. As with any treatment, unnecessary use, incorrect amounts or combining products can stress fish and reduce how well it works next time.
Fish
Some fish may show short-term stress, reduced appetite or hiding during treatment. If you notice severe distress such as rapid gill movement, loss of balance, gasping at the surface or fish lying on the bottom, stop treatment, improve aeration, do a partial water change and seek aquatic veterinary or professional guidance.
Birds
For non-food pet birds, use penicillin only under avian veterinary guidance. If your bird becomes unusually lethargic, stops eating or seems unwell, stop use and contact your avian veterinarian.
Invertebrates
Do not use Fix Pen in display tanks that hold shrimp, snails or other invertebrates, since penicillin may harm them or disrupt the tank. Whenever possible, move affected fish to a separate hospital tank.
Safe use in your system
Treat fish in a hospital or quarantine tank whenever you can, remove activated carbon and turn off UV sterilizers during treatment, and watch ammonia, nitrite and temperature closely. Do not mix Fix Pen with other treatments unless a veterinarian advises it.
Important safety note
Fix Pen is intended for ornamental aquarium fish and non-food pet birds only. It is not for animals raised for food. Store tablets in a cool, dry place away from direct sunlight, and keep them out of reach of children and pets. Always follow the directions on the label.
Shipping & Returns
Shipping Policy: Orders ship from our U.S. warehouse within 1 business day via USPS or UPS, with same-day dispatch on in-stock orders placed before 1:30 p.m. CT (Monday through Friday). For full shipping details, please see our shipping policy.
Refund Policy: If there is an issue with your order, you may be able to return or exchange items within 30 days according to our store guidelines. Before sending anything back, please review our refund policy carefully.
Frequently Asked Questions
What is Fix Pen used for?
Fix Pen is a fish penicillin tablet (500 mg) used to help manage suspected bacterial problems in ornamental aquarium fish, especially gram-positive infections such as fin rot, tail rot, infected wounds, pop-eye and columnaris-type lesions. For non-food pet birds, use penicillin only under avian veterinary guidance for usage and treatment decisions.
What is the difference between Fish Pen Forte and Fix Pen?
Fish Pen and Fish Pen Forte were brand names used by Thomas Labs for their penicillin tablets for fish. After Thomas Labs discontinued these products, Aqua Soma Labs introduced Fix Pen as a direct replacement. Fix Pen contains the same 500 mg Penicillin V Potassium per tablet and is intended for the same ornamental fish and pet bird uses.
Is Fix Pen a replacement for FISHBIOTIC Penicillin or Aqua Pen?
Yes. If you previously used FISHBIOTIC Penicillin, Aqua Pen or any other 500 mg penicillin tablet for fish, Fix Pen from Aqua Soma Labs is a direct replacement with the same penicillin, 500 mg of Penicillin V Potassium per tablet, available in 30-count and 60-count bottles.
How soon should I see improvement with Fix Pen?
Many keepers start to see early signs of a response by days 3 to 5, such as sores and red patches that stop spreading and appetite that begins to return. If there is no change by day 5, or the fish look worse, stop treatment and ask an aquatic professional about next steps. Finish the full treatment if the fish are improving.
Where can I buy penicillin tablets for fish online?
You can buy Fix Pen, a fish penicillin 500 mg tablet, directly from Fine Pet Health. We ship penicillin for fish and birds from our U.S. warehouse with same-day dispatch on in-stock orders placed before 1:30 p.m. CT, Monday through Friday, by USPS or UPS.
Each Fix Pen tablet contains 500 mg Penicillin V Potassium. Penicillin V works by interfering with bacterial cell wall formation, which helps control certain gram-positive bacteria when used as directed.
What is the Fix Pen amount for fish?
Follow the label directions: add one (1) 500 mg tablet per 20 gallons (76 L) of water you are treating, repeat every 24 hours and make a partial water change between doses. Continue for 5 to 10 days and stop if you see no improvement after 5 days.
How long should I treat with Fix Pen?
Label directions recommend treating for at least 5 days but no more than 10 days. If there is no improvement after 5 days, stop and reassess husbandry and next steps with an aquatic professional.
Should I treat in the main tank or a hospital tank?
A separate hospital or quarantine tank is strongly recommended. Penicillin and similar treatments may affect beneficial bacteria and can be risky for shrimp, snails, corals and other invertebrates, so dosing a display tank or reef setup is generally not a good idea. A small, dedicated hospital tank with a heater, air stone and no substrate makes dosing and water changes easier.
Do I need to remove activated carbon or turn off UV during treatment?
Yes. Activated carbon and some chemical filtration media can remove the penicillin from the water. Take them out during treatment and put them back afterward. Many keepers also switch off UV sterilizers during dosing to keep levels in the water steady.
Will Fix Pen harm beneficial bacteria in the aquarium?
It can. Penicillin, like other antibacterial treatments, may affect beneficial filter bacteria if used in the main tank. Using a hospital tank, watching ammonia and nitrite and doing partial water changes helps protect the biofilter during treatment.
Can Fix Pen be used in saltwater aquariums?
Yes. Fix Pen can be used in both freshwater and saltwater hospital tanks. Dissolve the tablet at the standard dose (one 500 mg tablet per 20 gallons) and keep salinity, temperature and water quality stable through the treatment.
Is Fix Pen safe for betta fish and small aquariums?
Yes. Fix Pen can be used in small hospital tanks for bettas and other individual fish. Because bettas are often kept in tanks under 20 gallons, you may need to split a tablet to reach the correct dose (one 500 mg tablet per 20 gallons). Dissolve the portion in a small cup of tank water before adding it to the hospital tank.
Can I use Fix Pen in a planted tank or with shrimp and snails?
It is generally considered compatible with most planted tanks, but penicillin may harm shrimp, snails and other invertebrates. When possible, move affected fish to a separate hospital tank to limit plant and biofilter exposure and to protect invertebrates.
Can Fix Pen treat fungal, viral or parasitic infections?
No. Fix Pen is a penicillin that targets certain bacterial infections only. It does not work against fungi, viruses or parasites such as ich, flukes or worms. For fungal, parasitic or viral problems, work with an aquatic or avian veterinarian to choose the right treatment.
Can I combine Fix Pen with other fish treatments?
Combining different treatments, or mixing Fix Pen with antifungal or antiparasitic products, is generally not recommended unless an aquatic veterinarian advises it. Using several products at once can stress fish, cause unpredictable interactions and make it harder to tell which one is working.
What should I do after finishing a Fix Pen treatment?
After the last dose, run a partial water change and put activated carbon back in to clear any leftover penicillin from the water. Keep watching ammonia and nitrite for a few days, since the biofilter can take time to recover, and only move fish back to the main tank once they are stable.
Can I use Fix Pen for dogs, cats or chickens?
Fix Pen is labeled for ornamental aquarium fish and non-food pet birds only. It is not formulated, tested or approved for dogs, cats, chickens or other mammals and food animals. If your dog or cat needs penicillin, a licensed veterinarian should recommend the correct product and amount for that species.
Can I use Fix Pen as penicillin for pet birds?
Fix Pen contains Penicillin V Potassium, the same penicillin used in avian care, so it can serve as a penicillin for birds option. Bird amounts are different from fish amounts and depend on the species and body weight, so use bird penicillin only under the direction of an avian veterinarian who can confirm a bacterial infection and set the amount and duration. Fix Pen is intended for non-food pet birds, not poultry raised for meat or eggs.
How should I store and dispose of Fix Pen tablets?
Store tablets in their original container in a cool, dry place away from heat, moisture, children and pets. Check the expiration date before use. For disposal, follow your local guidance for safe household disposal.
Bottom Line
Fix Pen is a fish penicillin 500 mg tablet (Penicillin V Potassium) for gram-positive bacterial problems in ornamental aquarium fish, and a vet-directed penicillin option for non-food pet birds. It is the current replacement for the discontinued Thomas Labs Fish Pen and Fish Pen Forte. Dose by water volume at one 500 mg tablet per 20 gallons, treat for 5 to 10 days in a hospital tank, and reassess at day 5. It will not help with fungal, viral or parasitic problems, and it is not for animals raised for food. If you are unsure whether the cause is bacterial, or you are treating a bird, talk to an aquatic or avian veterinarian first. Ready to start? Choose the size that fits your setup above, or compare the rest of the Fix line below.
More Fish & Bird Treatments
Fix Mox (Amoxicillin) 250/500mg A treatment for fin rot, dropsy, ulcers and other bacterial infections. Available in 30-count and 100-count capsules. Shop Fix Mox
Fix Zole (Metronidazole) 250/500mg Targets anaerobic bacteria and protozoa, including Hexamita and hole-in-the-head, in ornamental fish. Available in 60-count bottles. Shop Fix Zole
Fix Doxy (Doxycycline) 100mg A treatment for columnaris, respiratory infections and Mycoplasma in fish and birds. Available in 30-count and 60-count tablets. Shop Fix Doxy
Fix Zithro (Azithromycin) 250mg A treatment for fin rot, columnaris, gill disease and avian respiratory concerns. Available in 12-count and 30-count tablets. Shop Fix Zithro
Fix Cin (Clindamycin) 150mg A treatment commonly used for gram-positive bacterial infections, including skin and soft tissue concerns in ornamental fish. Shop Fix Cin
Fix Sulfa (SMZ/TMP) 960mg A combination treatment offering broad coverage against a range of bacterial infections in ornamental fish. Shop Fix Sulfa
Fix Flex (Cephalexin) 250/500mg A treatment for fin rot, ulcers and bacterial skin infections in fish and birds. Shop Fix Flex
Fix Flox (Ciprofloxacin) 500mg A treatment for gram-negative bacterial infections, including fin rot, ulcers, columnaris and septicemia in ornamental fish. Shop Fix Flox
Guides and care tips Visit the Fish & Bird Care Blog for practical dosing guides, water-care advice and treatment tips.
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Hi Stephanie, thank you for the 5-star review! We are very glad to hear that the Fix Pen is accurate and works exactly as it should for your fish or birds. We truly appreciate your support!
n
nmtsaki (Westland, MI)
Great products/Great service
I was worried about a couple of my fish, and decided I needed to treat with antibiotics ASAP. I picked a variety, just in case one didn’t work. Penicillin worked like a charm, and my fishes infections cleared up quickly. I owe Fine Pet a debt of gratitude because the antibiotics came quick and were of good quality/in date. As others have said, Fine Pet kept me updated the entire time so I knew exactly when my “cure” would be coming!
Thanks so much!
Hi nmtsaki, thank you so much for the incredibly detailed and kind review! We know exactly how stressful it is when your fish are sick and you need treatments ASAP. We are absolutely thrilled to hear the Fix Pen worked like a charm and that your aquarium is healthy again. Keeping you fully updated on shipping and providing fresh, high-quality products is our top priority. We truly appreciate your trust in us!
K
Kathy Carlson (Washington, IA)
Great price
High quality pet medication at a great price.
Hi Kathy, we really appreciate the perfect rating and the thumbs up on the Fix Pen! It’s great to know that you are pleased with both the quality and the price of the medication. Let us know whenever you need anything else!
T
T.M.
Easy to navigate website. Kept updated on shipping.
Hello Timothy! We are absolutely thrilled to receive your perfect rating. It is fantastic to know that you had a smooth shopping experience for your Fix Pen, from browsing our website to receiving those steady transit updates. We deeply appreciate your support and can't wait to see you back at our store whenever you need to restock!
M
Marion Mcbee (Concord, NC)
Fix Pen (Penicillin) Tablets Fish & Bird Antibiotic