These steps follow the Fix Sulfa 960 bottle label directions for SMZ/TMP use in ornamental aquarium fish.
Quick Usage Summary:
Dissolve one (1) dose (one tablet) and add it for every 40 gallons (151 L) of water to be treated. Repeat every 24 hours with a partial water change between treatments for 5 to 10 days. Discontinue use if no improvement is noted after 5 days.
Before You Dose:
-
Measure Water Volume
Calculate actual water volume (account for substrate, decor, and fill level).
-
Use a Hospital Tank
Use a hospital/quarantine tank when possible for better control and observation.
-
Remove Carbon and UV
Remove activated carbon and other chemical media; turn off UV sterilizers during treatment.
-
Boost Aeration
Increase aeration and surface agitation; keep temperature stable.
Directions for Use:
-
Dissolve and Add the Dose
Fully dissolve one (1) dose (one tablet) in a small cup of aquarium water, then add the dissolved dose to the treatment tank. Add one tablet per 40 gallons (151 L) of water to be treated.
-
Repeat Every 24 Hours
Repeat every 24 hours. Perform a partial water change between treatments throughout the treatment.
-
Complete the Treatment and Watch for Progress
Continue treatment for 5 to 10 days. Watch appetite, swimming behavior, fin condition, and any signs of stress. Discontinue use if no improvement is noted after 5 days. If fish appear worse or show severe stress, stop treatment and seek aquatic veterinary advice.
-
Post-Treatment Clean Up
After the treatment is complete, perform a partial water change and resume normal filtration. Replace activated carbon or chemical media if you removed it, and keep monitoring water parameters for several days to confirm stability.
Fix Sulfa Amounts by Aquarium Size
| Tank volume |
Fix Sulfa 960 amount |
How to measure |
| 10 gallons (38 L) |
1/4 tablet |
Split a scored tablet, or add 1/4 of one dissolved tablet |
| 20 gallons (76 L) |
1/2 tablet |
Split a scored tablet, or add 1/2 of one dissolved tablet |
| 40 gallons (151 L) |
1 tablet (label standard) |
Dissolve one whole tablet |
| 80 gallons (303 L) |
2 tablets |
Dissolve two whole tablets |
| 120 gallons (454 L) |
3 tablets |
Dissolve three whole tablets |
The Fix Sulfa 960 label states one (1) dose (one tablet) per 40 gallons (151 L), which is about 24 mg of combined sulfamethoxazole and trimethoprim per gallon. The 40-gallon row is the exact label instruction; the other rows scale that same rate. For tanks under 40 gallons you can split a scored tablet, or dissolve one tablet in a measured cup of tank water and add the matching fraction for more accuracy. Dose by your treatment tank's water volume, not the number of fish, repeat once every 24 hours for 5 to 10 days, and follow the bottle label or your aquatic veterinarian over this quick-reference chart.
What to Expect During Treatment
Days 1 to 2
Fish may hide or eat less, and the water can look slightly cloudy. This is normal early on. Keep dosing on schedule and keep aeration strong.
Days 3 to 5
Watch for signs it is working: sores and red patches stop spreading, appetite starts to return, and breathing steadies. If there is no change by day 5, or the fish look worse, stop and ask an aquatic veterinarian.
Days 5 to 10
Even if the fish are improving, finish all the recommended days so the infection does not return. Afterward, run a partial water change and put activated carbon back in to clear any leftover product.
What You Need for a Treatment
A little setup before the first dose saves trouble later.
- A separate hospital or quarantine tank, so you are not treating the whole display.
- A heater and an air stone or sponge filter for steady temperature and strong aeration.
- An ammonia and nitrite test kit to keep tabs on water quality.
- A dechlorinator for the water changes between doses.
- A small net and a clean cup for gentle transfer and measuring the dose.
Pro Tip: Hospital tank treatment helps protect the display aquarium, keeps the amount consistent, and makes it easier to keep ammonia and nitrite at 0 during recovery.