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Fix Zithro (Azithromycin) Tablets Fish & Bird Antibiotics

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Dose & Quantity

Fix Zithro (Bird Zithro) Azithromycin Tablets - Fish & Bird Antibiotic 250 mg

Fix Zithro 250 mg (often called Bird Zithro or Fish Zithro in the hobby community) is a trusted, broad-spectrum fish and bird antibiotic for ornamental aquarium fish and non-food pet birds. This fish azithromycin 250 mg tablet from the Aqua Soma Labs Fix range of aquarium fish antibiotics helps manage common problems such as fin and tail rot, columnaris, gill disease and other bacterial infections in freshwater and saltwater aquariums. Bird keepers also use it, under veterinary guidance, as a bird azithromycin option for mild respiratory infections or suspected Mycoplasma issues in pigeons and other pet birds. For aquarists looking for an azithromycin fish antibiotic or a modern replacement for older Bird Zithro or Aqua Zithro 250 mg products, Fix Zithro offers a focused solution for aquatic and avian collections.

Azithromycin is a macrolide antibiotic that works by interfering with bacterial protein synthesis, which helps slow or stop the growth of susceptible bacteria in the gills, skin and respiratory tract. When used as directed in fish or birds, azithromycin can be part of a broader management plan that also includes good husbandry, clean water and appropriate nutrition.

Fix Zithro from Aqua Soma Labs supplies 250 mg azithromycin per tablet and is available in bottles of 12 or 30 tablets, giving hobbyists flexible options, whether they maintain a single hospital tank, multiple community aquariums or a busy loft or aviary. It is a convenient choice when you need azithromycin for fish or azithromycin for birds and prefer one product that works across your aquatic and avian collections.

Important Notice: This product is intended for aquarium and ornamental fish and pet birds only. It is not for human consumption or for animals used for food. We do not sell or recommend this product for human use.

Use Fix Zithro when you notice early signs of bacterial stress such as clamped or frayed fins, red or cloudy patches on the body, gill irritation, listlessness or a persistent loss of appetite in fish, or sneezing, nasal discharge, ruffled feathers or reduced activity in birds. Addressing potential bacterial issues early with azithromycin treatment, together with good water quality, suitable housing and advice from an aquatic or avian professional when available, helps your fish and birds maintain a stable, healthy aquarium or aviary.


What Are the Benefits of Fix Zithro (Bird Zithro) Azithromycin 250 mg for Fish & Birds?

  • Broad-Spectrum Bacterial Support
    Fix Zithro (Bird Zithro) provides broad-spectrum azithromycin coverage for ornamental fish and non-food pet birds. It helps manage common problems such as fin and tail rot, columnaris, gill disease and early respiratory signs in birds when used as directed.

  • Helps With Internal and External Infections
    Azithromycin in Fix Zithro can be used as an azithromycin fish antibiotic for skin lesions, ulcers, fin damage and internal infections in a hospital tank, as well as part of a bird azithromycin plan for mild respiratory or Mycoplasma-related concerns.

  • Consistent 250 mg Fish Azithromycin Tablets
    Each tablet delivers a reliable 250 mg fish azithromycin dose, making it easier to scale treatment from a single betta or quarantine tank up to larger community aquariums, lofts or aviaries without complicated calculations.

  • Easy to Administer to Fish and Birds
    Tablets can be dissolved directly in aquarium water or mixed with soft food, providing flexible options for shy, stressed or hard-to-handle fish and birds while minimizing handling and extra stress.

  • Versatile for Freshwater, Saltwater & Aviary Setups
    Hobbyists reach for Fix Zithro as their trusted fish zithro choice in both freshwater and marine systems, and as a convenient bird azithromycin option for pigeons and other ornamental birds kept in lofts, cages or aviaries.

  • Ideal for Hospital Tanks and Quarantine
    Using Fix Zithro in a separate hospital tank or treatment cage helps protect the main aquarium’s biofilter and reduces unnecessary exposure of healthy tank mates or flock members while you focus treatment where it is needed most.


How to Dose & Use Fix Zithro (Bird Zithro) Azithromycin 250 mg for Fish & Birds

Directions for Use:

  1. Set Up a Separate Treatment Area
    Move affected fish to a dedicated hospital tank and, where practical, house birds needing treatment in a small treatment cage. This helps protect healthy tank mates or flock members and lets you control dosing more precisely.

  2. Dose for Fish Aquariums
    Dissolve one 250 mg tablet per 10 gallons (38 L) of water in the hospital tank. Mix the tablet in a small cup of aquarium water first, then distribute it evenly around the tank. Repeat the dose every 24 hours for 5–7 days while closely monitoring water quality and fish behavior. This is the standard Fix Zithro dosage for fish unless your aquatic veterinarian advises otherwise.

  3. Use in Pet Birds (Under Veterinary Guidance)
    Only administer Fix Zithro to pigeons and other pet birds under the direction of an avian veterinarian. Your vet can advise you on the correct mg-per-kg dose, frequency and duration. Tablets may be given whole, split, or crushed and mixed into soft food or drinking water exactly as instructed.

  4. Maintain Water Quality & Complete the Course
    Perform partial water changes as needed between doses to keep ammonia and nitrite low and ensure good aeration in the hospital tank. Continue treatment for the full recommended course even if fish or birds appear better; stopping early can allow symptoms to return. If there is no improvement after several days, or if signs worsen, consult an aquatic or avian professional.

Pro Tip: Always quarantine infected fish and birds away from healthy companions during treatment to reduce stress and help prevent the spread of disease.


What Makes Fix Zithro (Bird Zithro) Azithromycin 250 mg Effective?

  • Active ingredient: Azithromycin (250 mg per tablet)
    Azithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis, helping slow or stop the growth of susceptible bacteria in the gills, skin and respiratory tract of ornamental fish and non-food pet birds.

  • Inactive ingredients:
    Tablet excipients that help keep the azithromycin stable on the shelf and allow the tablet to disperse and dissolve properly when added to aquarium water or mixed with soft food.


Side Effects & Safety Tips for Fix Zithro (Bird Zithro)

When used as directed, Fix Zithro is generally well tolerated in ornamental fish and non-food pet birds. As with any azithromycin product, incorrect dosing or prolonged use can increase the risk of side effects and antibiotic resistance.

  • Fish: Azithromycin-based fish antibiotics may cause temporary stress or hiding behavior, mild water cloudiness and reduced appetite during treatment. If fish show severe distress such as rapid gill movement, loss of balance, gasping at the surface or lying on the bottom, stop treatment, improve aeration and seek aquatic veterinary advice.

  • Birds: When azithromycin is given in food or drinking water, possible reactions include decreased appetite, loose or changed droppings and lethargy, especially if the dose is too high or the bird is sensitive. If your bird appears fluffed up, inactive or stops eating, discontinue use and contact an avian veterinarian.

  • Invertebrates: Do not use Fix Zithro in display tanks that contain shrimp, snails or other invertebrates, as strong antibiotics may harm them or disrupt the tank ecosystem. Whenever possible, move affected fish to a separate hospital tank.

  • Safe use in your system: Treat fish in a hospital or quarantine tank whenever you can, remove activated carbon and turn off UV sterilizers during treatment, and monitor ammonia, nitrite and temperature closely. Do not mix Fix Zithro with other antibiotics unless advised by a veterinarian.

  • Important safety warning: Fix Zithro (Bird Zithro) is intended for ornamental aquarium fish and non-food pet birds only. It is not for human use and not for animals raised for food. Using fish or bird antibiotics in people instead of prescribed medicine can lead to treatment failure, serious side effects and antibiotic resistance. Store tablets in a cool, dry place away from direct sunlight and keep out of reach of children and pets. Always follow the directions on the label.


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FAQs About Fix Zithro (Bird Zithro) Azithromycin 250 mg for Fish & Birds

What is Fix Zithro (Bird Zithro) used for in fish and birds?
Fix Zithro (azithromycin 250 mg) is a fish and bird antibiotic used by hobbyists to help manage bacterial issues such as fin and tail rot, columnaris or gill disease in ornamental fish, and to support veterinarian-directed treatment of mild respiratory or Mycoplasma-related problems in non-food pet birds.

Is Fix Zithro the same as a fish Z-Pak or Bird Zithro?
Fix Zithro contains the same active ingredient as a human “Z-Pak” (azithromycin), but it is formulated and labeled for ornamental fish and pet birds only and is not a substitute for human medicine. Older listings may refer to similar products as Bird Zithro or fish zpack antibiotics.

How do I know if my fish might need a fish azithromycin antibiotic?
Watch for signs such as frayed or rotting fins, red or white ulcers, fuzzy patches that suggest columnaris, labored breathing or listless behavior that does not improve with good water quality. A fish veterinarian or experienced aquarist can help confirm whether a bacterial infection and azithromycin treatment are appropriate.

Can I use Fix Zithro in my main community or reef tank?
It is best to treat sick fish in a separate hospital tank instead of the main aquarium. Fix Zithro and other fish azithromycin products are not recommended for reef tanks or setups with shrimp, snails, corals or other invertebrates, because strong antibiotics may harm them or disrupt beneficial filter bacteria.

How long should I treat with Fix Zithro?
For fish, many hobbyists follow the label directions of one 250 mg tablet per 10 gallons (38 L) once every 24 hours for 5–7 days, or as advised by an aquatic veterinarian. Birds should only receive Fix Zithro for the dose and duration prescribed by an avian vet.

Is Fix Zithro safe for pet birds, and can I treat more than one bird?
Fix Zithro can be used in pigeons and other pet birds only under the direction of an avian veterinarian, who will calculate the mg per kg dose and decide whether to treat a single bird or an entire loft or flock. Never guess bird dosages or add tablets to communal water without professional guidance.

Will Fix Zithro harm beneficial aquarium bacteria?
Any broad-spectrum fish antibiotic, including azithromycin for fish, can affect beneficial bacteria if used in the main tank. Using a hospital tank, monitoring ammonia and nitrite, and performing partial water changes helps protect the biofilter while treatment is underway.

How quickly should I see improvement with Fix Zithro?
Many aquarists notice clearer skin, improved fin condition and more normal swimming or breathing within a few days once water quality is stable and the full course is followed. If fish or birds fail to improve or seem worse after several days, stop treatment and seek aquatic or avian veterinary advice.

Can Fix Zithro treat fungal, viral or parasitic infections?
No. Fix Zithro (Bird Zithro) is an azithromycin fish and bird antibiotic that targets certain bacterial infections. It is not effective against fungi, viruses or parasites such as ich, flukes or worms. For fungal, parasitic or viral problems, work with an aquatic or avian veterinarian to choose an appropriate treatment instead of using an antibiotic.

How should I store and dispose of Fix Zithro tablets?
Store tablets in their original container in a cool, dry place away from heat, moisture, children and pets. Follow local guidelines for pharmaceutical disposal and avoid flushing unused tablets down the drain unless specifically instructed by local authorities.


More Fish & Bird Antibiotics

Need another aquarium fish or pet bird antibiotic? Explore our Fish & Bird Antibiotics Collection for more Fix line and related treatments.

Looking for dosing and water-care advice? Visit the Fish & Bird Antibiotics Blog for practical guides and treatment tips.


About Fine PetHealth

Fine PetHealth focuses on aquarium fish and pet bird antibiotics and care products for hobbyists. Our guides are based on current product labels, manufacturer information and widely accepted aquatic and avian husbandry practices, translated into clear, practical language for everyday use.

  • Experience: Our team has years of hands-on experience maintaining community tanks, hospital setups and small home aviaries, so we understand the real-world challenges hobbyists face.
  • How we create guides: Before publishing a product guide, we review the label, cross-check details with manufacturer resources and compare them with other reputable references, then organize the information into step-by-step instructions and FAQs.
  • Not a substitute for a vet: Our content is educational and is not a replacement for diagnosis or treatment from an aquatic or avian veterinarian. Whenever you are unsure about symptoms or dosing, we recommend seeking professional veterinary advice.
  • Ongoing updates: We regularly review and update our Fix line pages as product information, regulations or best-practice recommendations change, so you always see our most current guidance.