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Fix Zole (Fish Zole) Metronidazole 250/500mg 60ct Fish Antibiotic

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Fix Zole (Fish Zole) Metronidazole Tablets - Fish & Bird Antibiotic 250 mg / 500 mg

Fix Zole at a Glance
Active Ingredient Metronidazole
Strength 250 mg or 500 mg per tablet
Form Tablets
Bottle Size 60 count
Drug Class Nitroimidazole
For Ornamental aquarium fish & non-food pet birds
Manufacturer Aqua Soma Labs
Prescription Not required (over-the-counter)

Fix Zole (Fish Zole) Metronidazole 250mg and 500mg is a metronidazole fish and bird antibiotic in tablet form. Shoppers also look for it as fish metronidazole, fishzole, or by older brand names like Fish Zole Forte, Aqua Zole, and aquazole. It is now made by Aqua Soma Labs and sold over the counter, replacing the discontinued Thomas Labs Fish Zole. If you have used MetroPlex in the past, this is a tablet-based alternative.

Hobbyists use Fix Zole to help manage internal parasites and intestinal flagellates (protozoan flagellates) such as Hexamita and Spironucleus. These can show up in several ways in susceptible freshwater fish, from feeding and behavior changes to visible physical signs (see the symptom list below). Many keepers prefer treating in a hospital tank or quarantine setup for easier observation and control.

Metronidazole is a nitroimidazole medication with activity against certain protozoa and anaerobic organisms by disrupting DNA processes in susceptible targets. When used as directed, it can be part of a broader care plan that also includes stable water quality, reduced stress, and good nutrition. It is not intended for ich or flukes, and it is not a first choice for typical fin rot unless a professional has confirmed the cause.

Fix Zole from Aqua Soma Labs delivers 250 mg or 500 mg metronidazole per tablet in 60-count bottles with fresh expiration dates. Pick the strength that matches your tank size and treatment plan, with no splitting or measuring. You can pre-dissolve a tablet in a small cup of aquarium water before adding it to a treatment tank, which helps it spread evenly.

Use Fix Zole when fish or pet birds show signs that may be linked to protozoan flagellates or anaerobic-sensitive issues. Common signs differ between species, so check the lists below to identify what to watch for.

Fish-Specific Symptoms

  • Loss of appetite, gradual weight loss
  • White stringy droppings
  • "Hole-in-the-head" lesions (pits on head and lateral line)
  • Malawi bloat (cichlid bloat), swollen abdomen
  • Faded color, darkening, or body discoloration
  • Lethargy, hiding, reduced activity
  • Sudden death in cichlids and discus (Hexamita / Spironucleus)

Bird-Specific Symptoms (Under Avian Vet Guidance)

  • Yellow plaques in throat or crop (canker / trichomonosis)
  • Pigeon canker, especially in racing pigeons
  • Frounce in raptors (falcons, hawks, owls)
  • Loose or watery droppings (possible giardia)
  • Reduced appetite, weight loss
  • Difficulty swallowing or visible discomfort when eating
  • Fluffed-up feathers, lethargy

Supporting treatment with clean water, stable temperature, and appropriate husbandry helps reduce setbacks and improve outcomes. For pet birds, always confirm the diagnosis with an avian veterinarian before administering metronidazole.

Order online: Fix Zole ships directly from our U.S. warehouse the same business day. No veterinary prescription required for aquarium fish use.

Important Notice: This product is intended for aquarium and ornamental fish and pet birds only. It is not for human consumption or for animals used for food. We do not sell or recommend this product for human use.


Fish Zole vs Fix Zole: What Changed?

If you previously used Thomas Labs Fish Zole, Fish Zole Forte, or Aqua-Zole by Aqua Soma Labs, here is what you need to know about Fix Zole:

Same as Fish Zole, Fish Zole Forte, and Aqua-Zole
Fix Zole uses the same metronidazole that hobbyists relied on under the Thomas Labs Fish Zole, Fish Zole Forte, and Aqua Soma Labs Aqua-Zole names, at 250 mg or 500 mg per tablet.

New Manufacturer
Produced by Aqua Soma Labs, which now manufactures the Fix line of fish and bird antibiotics (Fix Mox, Fix Doxy, Fix Zole) after Thomas Labs discontinued its Fish Zole product.

Same 60-Count Bottles
Each bottle contains 60 tablets, the same count hobbyists expect. Choose 250 mg or 500 mg to match your tank size and treatment plan.

Updated Packaging, Same Formula
The label and brand name are new. The metronidazole inside is the same formula the hobby has used for years.


Benefits of Fix Zole for Fish & Birds

  • Targeted Protozoan Support

    Commonly used to help manage internal parasites and protozoan flagellates such as Hexamita and Spironucleus, which are often associated with appetite loss, weight loss, white stringy poop, Malawi bloat, and "hole-in-the-head" type signs in susceptible freshwater fish such as cichlids and discus.

  • No Veterinary Prescription Required

    Fix Zole is available over the counter for aquarium fish use. No vet prescription or doctor's visit is needed to purchase. For pet birds, always consult an avian veterinarian before administering metronidazole.

  • Avian Vet-Guided Option

    In non-food pet birds, metronidazole may be used under avian veterinary guidance for certain protozoal concerns such as giardia, frounce (common in raptors), and as an effective pigeon canker treatment for trichomonosis, especially in racing pigeons and related species.

  • Flexible 250 mg or 500 mg per Tablet

    Choose the strength that fits your setup and plan. A consistent mg per tablet (in 60-count bottles) lets you scale the dose across different tank sizes or care routines.

  • Ideal for Hospital Tanks and Quarantine

    Many hobbyists treat in a separate hospital tank for better observation and to help protect the display tank's biofilter and sensitive tank mates. Tablets can be pre-dissolved in a small cup of aquarium water for more even distribution.

  • Fits a Complete Care Plan

    Medication alone rarely fixes the problem. The best results come when you also keep the temperature stable, the water clean, stress low, and feeding appropriate.

  • Targeted, Not a One-Size-Fits-All Remedy

    Fix Zole is not typically used for ich (white spot), gill flukes, or Costia, and it is not a first choice for typical fin rot unless the cause has been confirmed. If symptoms persist, confirm the diagnosis or consult an aquatic or avian professional.


Dosage Guidelines & Instructions

Directions for Use:

  1. Set Up a Separate Treatment Area

    Move affected fish to a dedicated hospital tank when possible. This helps you monitor behavior, control dosing more precisely, and reduce unnecessary exposure in the display aquarium.

  2. Dose for Fish Aquariums

    You may pre-dissolve the tablet in a small cup of aquarium water, then distribute it evenly across the fish tank you are treating:

    250 mg: Add one 250 mg tablet per 10 gallons (38 L) of water.
    500 mg: Add one 500 mg tablet per 20 gallons (76 L) of water.

    Repeat the dose every 24 hours, performing a partial water change between treatments.

  3. Filter Adjustments

    Remove activated carbon or other chemical filtration media during treatment and keep good aeration running, since carbon can reduce medication availability in the water.

  4. Continue the Course and Monitor Results

    Continue daily treatment for 5 to 10 days (do not exceed 10 days). If there is no improvement within 5 days, discontinue treatment and consult an aquatic professional.

  5. Use in Pet Birds (Under Veterinary Guidance)

    Only administer metronidazole to non-food pet birds under the direction of an avian veterinarian. Your vet should confirm the diagnosis and advise the correct mg-per-kg dose, frequency, and duration. Tablets may be given whole, split, or crushed and mixed into soft food exactly as instructed.

Fix Zole Dosing by Aquarium Size
Tank volume Metronidazole per dose 250 mg tablets 500 mg tablets
10 gallons (38 L) 250 mg 1
20 gallons (76 L) 500 mg 2 1
30 gallons (114 L) 750 mg 3 1 + one 250 mg
40 gallons (151 L) 1000 mg 4 2
55 gallons (208 L) about 1375 mg 5 to 6 3

These figures come from the label-style guideline of 250 mg per 10 gallons, roughly 25 mg per gallon. Dose by the water volume of your treatment tank, not by the number of fish, give one dose every 24 hours for 5 to 10 days, and round to the nearest practical tablet. The bottle label or your aquatic veterinarian takes priority over this quick-reference chart.

What to Expect During Treatment

Days 1 to 2

Fish may hide or eat less while the medication takes hold. This is normal early on. Keep dosing on schedule and keep aeration strong.

Days 3 to 5

Look for signs it is working: appetite picking back up, droppings returning to normal, steadier activity. If nothing has changed by day 5, or the fish look worse, stop and ask an aquatic veterinarian.

Days 5 to 10

Even if the fish are improving, finish the full course so the problem does not return. Afterward, run a partial water change and put activated carbon back in to clear any leftover medication.

What You Need for a Treatment Course

Get these ready before the first dose:

  • A separate hospital or quarantine tank, so you are not medicating the whole display.
  • A heater and an air stone or sponge filter for steady temperature and strong aeration.
  • An ammonia and nitrite test kit to keep tabs on water quality.
  • A dechlorinator for the water changes between doses.
  • A small net and a clean cup for gentle transfer and pre-dissolving the tablet.

Pro Tip: After treatment, perform a partial water change and reintroduce activated carbon (if you normally use it) to help remove residual medication from the water.


How This Medication Works

  • Active Ingredient: Metronidazole (250 mg or 500 mg per tablet)

    Metronidazole is a 5-nitroimidazole medication that is activated in susceptible anaerobic organisms and certain protozoa. During activation, short-lived reactive intermediates can damage DNA and disrupt cellular function in these targets. Hobbyists may also recognize metronidazole tablets under earlier names such as Thomas Labs Fish Zole, Fish Zole Forte, and Aqua-Zole, or as the "fish Flagyl" some keepers ask for, since flagyl for fish is simply the same active ingredient found in the prescription medication Flagyl.

  • Inactive Ingredients

    Like most tablets, Fix Zole includes inert excipients (such as binders and stabilizers) that help the tablet hold its shape, store well, and dissolve or disperse when mixed with water. The exact excipient list is not always published and may vary by batch.


Side Effects & Safety Tips

When used as directed, Fix Zole (metronidazole) is generally well tolerated in ornamental aquarium fish and non-food pet birds. Incorrect dosing, prolonged use, unnecessary repeat courses, or combining treatments can increase the risk of stress and side effects.

  • Fish

    Possible reactions include temporary reduced appetite, mild lethargy, or hiding behavior. If you see severe distress (rapid gill movement, loss of balance, gasping at the surface, or lying on the bottom), stop treatment, increase aeration, perform a partial water change, and seek aquatic veterinary advice.

  • Birds

    Use metronidazole only under avian veterinary guidance. Possible reactions may include decreased appetite, loose or changed droppings, and lethargy, especially if the bird is sensitive or the dose is not correct. If your bird appears fluffed up, inactive, or stops eating, discontinue use and contact an avian veterinarian.

  • Invertebrates

    Sensitivity can vary by species. Whenever possible, treat fish in a separate hospital tank instead of dosing a display aquarium that contains shrimp, snails, corals, or other invertebrates. If needed, relocate sensitive invertebrates before treatment.

  • Safe Use in Your System

    Do not mix Fix Zole with other antibiotics or medications unless advised by a professional. Avoid routine preventative dosing. If symptoms persist or return, confirm the diagnosis before repeating a course.

  • Storage & Handling

    Store at controlled room temperature of 59 to 86 F (15 to 30 C) in a cool, dry place. Keep the container tightly closed to protect tablets from moisture and light. Keep out of reach of children and pets.

  • Important Safety Warning

    Fix Zole is intended for ornamental aquarium fish and non-food pet birds only. It is not for human use and not for animals raised for food. Always follow label directions.


Shipping & Returns

Shipping Policy: Orders ship from our U.S. warehouse within 1 business day via USPS or UPS, with rates and delivery times calculated at checkout. For full details, see our shipping policy.

Refund Policy: If there is an issue with your order, you may be able to return or exchange items within 30 days according to our store guidelines. Before sending anything back, please review our refund policy carefully.


Frequently Asked Questions

What is Fix Zole used for in aquarium fish and pet birds?
Fix Zole (metronidazole) is commonly used by hobbyists to help manage certain protozoan concerns in ornamental aquarium fish, including issues often associated with Hexamita, Spironucleus, and internal parasites. In non-food pet birds, metronidazole may be used only under avian veterinary guidance for confirmed protozoal concerns such as canker (trichomonosis).
What is the active ingredient in Fix Zole?
The active ingredient in Fix Zole is metronidazole, available in 250 mg or 500 mg per tablet. Metronidazole is a 5-nitroimidazole-class medication active against certain protozoa (such as Hexamita and Spironucleus) and anaerobic organisms by disrupting DNA processes in susceptible targets.
What does metronidazole treat in fish?
In aquarium fish, metronidazole is mainly used for protozoan flagellates such as Hexamita and Spironucleus, the organisms often behind hole-in-the-head disease, white stringy droppings, and unexplained wasting in cichlids and discus. It does not treat ich, flukes, fungus, or most typical fin rot, which need different medications.
Is Fix Zole the same as Fish Zole or Fish Zole Forte?
Fix Zole contains the same active ingredient hobbyists have historically searched for as Thomas Labs Fish Zole, Fish Zole Forte, Aqua-Zole, or fishbiotic metronidazole. The 250 mg option stands in for the standard Fish Zole strength, and the 500 mg option is the Fish Zole Forte equivalent. Product names and directions can vary, so always follow the instructions for the specific product you have.
Is Fix Zole the same as Aqua-Zole by Aqua Soma Labs?
Yes. Aqua-Zole was an earlier brand name; Fix Zole is the current Aqua Soma Labs metronidazole product, with the same metronidazole at 250 mg or 500 mg per tablet in 60-count bottles. The active ingredient, strength, and intended use remain the same; only the brand name and packaging have been updated.
Is Fix Zole a human Flagyl alternative?
No. Fix Zole is not a human Flagyl alternative. It contains metronidazole, but it is made and sold as a medication for ornamental aquarium fish and non-food pet birds only. It must never be taken by humans, prescribed to yourself, or given to animals raised for food.
Is Fix Zole the "fish Flagyl" equivalent?
Fix Zole contains metronidazole, which is the same active ingredient found in the human-prescription medication Flagyl. Aquarium hobbyists sometimes use "fish Flagyl" as informal shorthand for metronidazole intended for ornamental fish use. Fix Zole is made and sold only for ornamental aquarium fish and non-food pet birds. It must never be used as a substitute for prescribed human Flagyl.
Do I need a veterinary prescription to buy Fix Zole?
No prescription is required to purchase Fix Zole for aquarium fish use. It is sold over the counter as a fish and bird medication. For pet birds, always consult an avian veterinarian before administering metronidazole to confirm the diagnosis and correct dosage.
How do I choose 250 mg vs 500 mg tablets?
Pick by water volume, not by how sick the fish looks. The label-style guide is one 250 mg tablet per 10 gallons (38 L) or one 500 mg tablet per 20 gallons (76 L), so the 500 mg simply covers a larger tank with fewer tablets. Pre-dissolve in tank water, or, if a vet directs it for a specific case, mix into medicated fish food. Do not pick a strength by guessing severity.
Can I give Fix Zole to my dog or cat?
Fix Zole is labeled for ornamental aquarium fish and non-food pet birds only. Metronidazole is common in medicine for dogs and cats (often as Flagyl) for giardia, IBD, and some infections, but the right dose depends on the animal's weight and the format differs from a fish tablet. Do not give Fix Zole to a dog or cat without a licensed veterinarian confirming the diagnosis and dose.
Does metronidazole help with hole-in-the-head symptoms?
Metronidazole is commonly used when hole-in-the-head type signs and white stringy poop are suspected to be linked to protozoan flagellates (such as Hexamita or Spironucleus). Not all cases have the same cause, so stable water quality, nutrition, and diagnosis matter just as much as medication.
Will Fix Zole treat ich (white spot) or gill flukes?
No. Metronidazole is not typically used for ich (white spot) or gill flukes. If symptoms suggest ich or flukes, choose a treatment that targets those parasites instead of using an antibiotic.
Can Fix Zole treat fin rot or other bacterial infections?
Metronidazole is mainly chosen for certain protozoan concerns and anaerobic-sensitive issues. It is not a first choice for typical fin rot unless a professional has confirmed the suspected cause and recommended metronidazole as part of a plan.
Can I use Fix Zole to prevent infections or as routine preventative dosing?
No. Fix Zole is intended for active, suspected, or confirmed issues, not routine prevention. Unnecessary use can increase stress on fish and can contribute to medication resistance over time.
How long should I treat with Fix Zole?
Many hobbyists follow daily dosing for 5 to 10 days (do not exceed 10 days). If there is no improvement within 5 days, discontinue treatment and consult an aquatic professional to confirm the cause and next steps.
How much metronidazole do I use per gallon, and how do I mix it?
The standard metronidazole for fish dosage follows a label-style guide of 250 mg per 10 gallons (38 L) of water, roughly 25 mg per gallon, or 500 mg per 20 gallons (76 L). Pre-dissolve the tablet in a small cup of tank water, then spread it evenly around the treatment tank. Dose by water volume, not by the number of fish, and repeat every 24 hours with a partial water change between doses. The dosing chart above lists common tank sizes.
Is Fix Zole safe in saltwater tanks?
Yes. Dosing goes by water volume, so metronidazole works the same in a freshwater or saltwater treatment tank. Treat in a hospital tank where you can, so monitoring is easier and sensitive animals in the display stay out of it.
Is Fix Zole reef-safe or safe with shrimp and snails?
Play it safe. Sensitivity differs by species, so do not dose a display tank that holds shrimp, snails, corals, or other invertebrates. Treat the affected fish in a separate hospital tank instead.
Can I combine Fix Zole with other medications?
Avoid mixing medications unless advised by an aquatic or avian professional. Remove activated carbon and other chemical filtration media during treatment, turn off UV sterilizers, maintain strong aeration, and monitor ammonia and nitrite.
How do I administer metronidazole to pet birds?
Only administer metronidazole to non-food pet birds under avian veterinary guidance. Your vet should confirm the diagnosis and provide the correct mg-per-kg dose, frequency, and duration. Never guess bird dosages or add tablets to communal drinking water without professional direction.
Is this the same metronidazole humans use?
It shares the same active ingredient name, but Fix Zole is intended for ornamental aquarium fish and non-food pet birds only. Never use it as a substitute for human medicine.
Where can I buy metronidazole for fish online?
If you are wondering where to buy metronidazole for fish, you can order Fix Zole (metronidazole) directly from Fine Pet Health. Orders ship from our U.S. warehouse the same business day via USPS or UPS, with no veterinary prescription required for aquarium fish use.
Browse Fish & Bird Antibiotics Collection →

More Fish & Bird Antibiotics

Fix Mox (Amoxicillin) 250/500mg A broad-spectrum penicillin-type fish antibiotic for fin rot, dropsy, ulcers and other bacterial infections. Available in 30-count and 100-count capsules. Shop Fix Mox

Fix Doxy (Doxycycline) 100mg A tetracycline-class fish and bird antibiotic effective against columnaris, respiratory infections and Mycoplasma. Available in 30-count and 60-count tablets. Shop Fix Doxy

Fix Zithro (Azithromycin) 250mg A macrolide fish and bird antibiotic for fin rot, columnaris, gill disease and avian respiratory concerns. Available in 12-count and 30-count tablets. Shop Fix Zithro

Fix Cin (Clindamycin) 150mg A lincosamide fish antibiotic commonly used for gram-positive bacterial infections including skin and soft tissue concerns in ornamental fish. Shop Fix Cin

Fix Sulfa (SMZ/TMP) 960mg A sulfonamide combination fish antibiotic offering broad-spectrum coverage against a range of bacterial infections in ornamental fish. Shop Fix Sulfa

Fix Pen (Penicillin) 500mg A penicillin-type fish and bird antibiotic for gram-positive bacterial infections in ornamental fish and non-food pet birds. Shop Fix Pen

Fix Flex (Cephalexin) 250/500mg A first-generation cephalosporin fish and bird antibiotic for fin rot, ulcers and bacterial skin infections in ornamental fish. Shop Fix Flex

Fix Flox (Ciprofloxacin) 500mg A fluoroquinolone fish and bird antibiotic for gram-negative bacterial infections including fin rot, ulcers, columnaris and septicemia in ornamental fish. Shop Fix Flox

Browse all treatments Explore our complete Fish & Bird Antibiotics Collection for more Fix line products and related treatments.

Guides and treatment tips Visit the Fish & Bird Antibiotics Blog for practical dosing guides, water-care advice and treatment tips.


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About Fine PetHealth and How We Verify Our Antibiotic Guides

Who is responsible for this page: Fine PetHealth Editorial Team.

Verification snapshot: This guide is written from the current product label for this item and reviewed for accuracy and consistency before publishing.

How we verify product information (our checklist):

1) Label-first accuracy: Dosing, duration, storage, and warnings are taken from the current product label for this item.

2) Ingredient validation: Active ingredient names are cross-checked against reputable references (for example, NIH PubChem) to reduce the risk of labeling mistakes.

3) Consistency checks: We review for internal consistency (the same dosing and storage language across sections) and remove wording that could overpromise results.

4) Updates: We update pages when label directions, packaging, or manufacturer information changes.

What we don’t do: We don’t invent diagnoses, and we don’t create dosing instructions beyond what the product label states for this item’s intended use.

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Educational use: Our content is for informational purposes and is not a substitute for diagnosis or treatment from an aquatic or avian veterinarian.

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